Probing the molecular determinants of fluorinase specificity.

نویسندگان

  • W L Yeo
  • X Chew
  • D J Smith
  • K P Chan
  • H Sun
  • H Zhao
  • Y H Lim
  • E L Ang
چکیده

Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold activity improvement), and conferred novel activity towards substrates not readily accepted by wild-type FlA1.

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عنوان ژورنال:
  • Chemical communications

دوره 53 17  شماره 

صفحات  -

تاریخ انتشار 2017